Protein Details: Voltage-gated Potassium channel-interacting protein 2
Protein ID
ICDB_Pro_1548
Protein Name
Voltage-gated Potassium channel-interacting protein 2
Gene Name
Kcnip2; Kchip2
Organism
Rattus norvegicus (Rat)
Length
270 amino acids
AlphaFoldDB
AF-Q9JM59-F1-model_v4.pdb
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro; modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart (By similarity). Required for normal protein levels of KCND2 in the heart ventricle (By similarity)
Sequence
PDB Structures
Ligand Binding
Binding Site
153;155;157;159;164;189;191;193;195;200;237;239;241;248
Disease
Location
Expressed in heart; brain and lung. In brain; abundantly expressed in striatum; hippocampus and olfactory bulb; moderately expressed in cerebral cortex and lowly expressed in thalamus and hypothalamus. Isoform 1 is predominant in cerebral cortex; striatum and hippocampus. Isoform 1; isoform 2 and isoform 3 are equally expressed in olfactory bulb. Iisoform 3 is expressed at high levels and isoform 1 at low levels in heart (in PubMed:11263977).
DOI ID
10.1006/bbrc.2001.4558; 10.1074/jbc.m203651200; 10.1101/gr.2596504; 10.1038/35000592; 10.1152/ajpcell.00416.2002; 10.1074/jbc.m604843200; 10.1038/ncomms1871; 10.1007/s00424-014-1521-3
RefSeq
NP_001029133.1 [Q9JM59-3]; NP_064479.2 [Q9JM59-1]; NP_064480.2 [Q9JM59-2]; XP_008758701.1; XP_008758702.1; XP_008758704.1; XP_017445315.1; XP_017445321.1; XP_017445328.1